Pharmacokinetics of atracurium and its metabolites.
نویسندگان
چکیده
The pharmacokinetic profile of atracurium was studied in normal patients and in patients with renal failure, renal-hepatic failure, or hepatic disease. Its short elimination half-life was not significantly altered by renal failure, but in patients with severe liver disease elimination of its metabolites was prolonged, necessitating care during long-term i.v. infusions in patients with hepatic dysfunction.
منابع مشابه
Pharmacokinetics and neuromuscular blocking effects of atracurium besylate and two of its metabolites in patients with normal and impaired renal function.
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متن کاملPharmacokinetics of atracurium.
Sir,—We congratulate Drs Beetner, Bjorksten and Crankshaw on their description of the pharmacokinetics of atracurium [1]. As they observe correctly, the derivation of pharmacokinetic parameters after a single bolus dose is subject to difficulties because of the presumed degradation of atracurium in sites peripheral to the plasma. In our view, however, the crucial flaw in previous attempts to de...
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We have defined the pharmacokinetics of atracurium besylate 0.25 mg kg-1 in 41 patients anaesthetized with 0.9% isoflurane end-tidal, 0.5% halothane end-tidal or midazolam 3-10 mg as a supplement to 66% nitrous oxide in oxygen. The pharmacokinetic profile was affected by age, sex and anaesthetic technique. Advancing age was associated with a reduced clearance and a longer elimination half-time;...
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 58 Suppl 1 شماره
صفحات -
تاریخ انتشار 1986